11m 52s: Lenght

In this video we make p-chlorophenyl acetonitrile from the p-chlorobenzyl chloride and the sodium cyanide in a previous video. ( Complete pyrimethamine playlist so far: https://www.youtube.com/playlist?list=PLU79801KtVAU1XsTwHaKkqQoBgz_VYmPS ) Fortunately this is a very mild process and doesn't need exotic conditions like ultraviolet light or high temperatures. We reflux together 7.2g of potassium iodide, 19g of sodium cyanide, 50g of p-chlorobenzyl chloride and 250mL of dry acetone for at least one full day. What happens is the iodide replaces the benzylic chloride on the p-chlorobenzyl chloride in a reaction known as the Finkelstein reaction. This highly reactive p-chlorobenzyl iodide now reacts with sodium cyanide to form p-chlorobenzyl cyanide, or p-chlorophenyl acetonitrile. To recover it, first filter the salts from the acetone solution. The salts should be destroyed with an oxidant to render the sodium cyanide harmless. The filtrate is distilled to remove acetone. The residue is washed with 150mL water and 15g sodium metabisulfite solution. the denser organic phase is extracted off and washed again. the organic phase now consists mostly of p-chlorophenyl acetonitrile with some p-chlorobenzyl amine as the next most significant impurity. Donate to NurdRage! Through Patreon (preferred): https://www.patreon.com/NurdRage Through Bitcoin: 1NurdRAge7PNR4ULrbrpcYvc9RC4LDp9pS Glassware generously provided by http://www.alchemylabsupply.com/ Use the discount code "nurdrage" for a 5% discount. Social media links: Twitter: https://twitter.com/NurdRage Facebook: https://www.facebook.com/NurdRageYoutube/ Instagram: https://www.instagram.com/nurdrageyoutube/ This video generously sponsored by my patrons: Jon Stanovich Michael Zappe Emil Mikulic Alex S. My P. Nis Lord Martin Hill Matthew Brunette Simon Bitdiddle Cullen Purkis Carl Potter Zane Bacon Roger Martel DuVigneaud Bryan Boettcher Dror Kronstein Michael Gregg Robert Boll Nick Kinnan doug dysart william tips Daniel Astbury Shutaro Highwind Stephen Stair Bobby Nansel Andrea Nall Dom Vasta Tyler Bushey Michael Syam Krishnan Mark Rose Phillip Hutchings Uocjat Marius Klimantavičius Dino Capiaghi Henry Wu steve Antton Tapani Evan Schuld Mecha Chocobo Jason King David Gilmour Dean Bailey Matt Sieker Ben Anderson Jeremy Porter Chase Curtis Connor Reed Wolf Bennett Christian Cooper Samuel Pelzer Wesley Gardner Gabriel Jeantelot Kremling Brian Nietfeld Jean-Marc Bélisle Leon Verrall Feliksas Egan Loughran George Jefferies Syniurge evan Applied Science Micha Gorelick Hanna Anderberg Marcio Yukio Teruya Timothy Vincent Chris M Guerra Patrick Sweetman Collin B Douglas Daniel L. Michal Z Florent Parent Thor Danny Chan Miguel-Angel Gutierrez Casey Kikendall David Drueding Kay Bærulfsen Adrian Kleven Mark Beeunas David Craig House John Bonnin Triple Cee Rauni Kangas Daniel Åland Stephen Andrew Montagne Lior Z.L Joshua L Digiacomo Samuel Ytterbrink Tristan Putzeys Randi Silva Ed McMullen nBoost Output Coupler Xandorcode Al Longley Ariesticnig Greg Emmons Woobly Mark L Pascal De Lisio Tazobactam Emil Lund Jonathan Bear Joshua Crager Rebecca Chung Zach Schneider cj6xu6ru Johann Massyn Goodwine Meyer Bill Noren Joshua Books OpenArms Jason Brammer Paul Grodt Mark Keibler Bas Hessels Joshua Rogers upsidedownoj Julian Nicolai Herbert999 Myndert Papenhuyzen Dean Leggo Tyler Faruque Ross Clark Damien P Kevin C Akshay Joshi Rob Parker Robin Beckett James McIlhargey LVE LFTRnow Magnus Ott Kartin Marc Ethier rd Bob Drucker Kelvin Sac LeGaie Aner Nitsan Donald W Ricardo Hy Diep John Wasser Jeffrey Morse Braxton Thomason Åsmund Tveten CNK054so Essimage Marius Grey Shot Leonard Marshall jMe4505 Timothy Glore